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Unlike other morphine derivatives, heroin, or other opioid narcotics, carfentanil does not lead to addiction. It is too powerful for humans who have not developed a tolerance to strong narcotics like heroin or fentanyl. Even for people who have struggled with addiction to powerful narcotics, a dose the size of a grain of salt can rapidly lead to an overdose and death.
However, carfentanil has been found cutting heroin and even fentanyl sold on the streets, starting in July 2016 in Ohio, when 35 overdoses and six deaths occurred in a span of three days. Law enforcement and emergency medical personnel warn that carfentanil sold illicitly looks like other drugs found on the street, including cocaine and heroin, because it is an odorless, white powder. Carfentanil, like fentanyl, has been found cutting heroin in order to increase its potency and the heroin dealer’s supply of the substance.
While adding fentanyl to heroin has led to an epidemic of overdoses, carfentanil has led to deadly overdoses much faster. For comparison, according to Elephant Care International, the dose of carfentanil safely administered to sedate a wild adult male African elephant, which can weight over 1 ton, is only 13 mg. A dose of fentanyl, 100 times less powerful than carfentanil, that can safely be administered to a human adult is up to 100 micrograms per hour – the equivalent of 0.1 mg. The dose for the elephant is equivalent to 13,000 micrograms of carfentanil, which is about 1.3 million micrograms of fentanyl. Hence, 1,000 mg of fentanyl, the equivalent in potency of 1 mg of carfentanil, will easily kill a human.
According to an article from the Washington Post, carfentanil’s deadliness can be expressed in a few ways. First, the Buffalo Field Campaign based out of Yellowstone National Park warns that humans should not eat the meat of bison who have been sedated with carfentanil, because it can enter the human’s body and cause an overdose. Second, Russian authorities used a weaponized chemical gas based on carfentanil to end a Chechen hostage crisis in 2002 and ended up killing 170 people with one dose.
The dose used to cut heroin is typically so small that forensic chemists often have a hard time finding it. Even so, that small amount is enough to send a person into an overdose. The Ohio Attorney General website recommends that forensic technicians and chemists who must field-test heroin for fentanyl or carfentanil use protective gear to avoid harming or killing themselves.
Buy Carfentanil Powder Online acts primarily on the mu (some kappa and delta) opioid receptors as an agonist. It will induce similar effects of analgesia as other opioids, however, due to its potency, it will also induce strong side effects such as sedation. Consequently, that is why it is used as a tranquilizer for large animals. Carfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the brain, spinal cord, and other tissues. It exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Carfentanil also depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Buy Carfentanil Powder Online is an ultra-potent synthetic opioid. No human carfentanil metabolism data are available. Reportedly, Russian police forces used carfentanil and remifentanil to resolve a hostage situation in Moscow in 2002. This alleged use prompted interest in the pharmacology and toxicology of carfentanil in humans. Our study was conducted to identify human carfentanil metabolites and to assess carfentanil’s metabolic clearance, which could contribute to its acute toxicity in humans. We used Simulations Plus’s ADMET Predictor and Molecular Discovery’s MetaSite to predict possible metabolite formation. Both programs gave similar results that were generally good but did not capture all metabolites seen in vitro. We incubated carfentanil with human hepatocytes for up to 1 hr and analyzed samples on a Sciex 3200 QTRAP mass spectrometer to measure parent compound depletion and extrapolated that to represent intrinsic clearance. Pooled primary human hepatocytes were then incubated with Buy Carfentanil Powder Online up to 6 h and analyzed for metabolite identification on a Sciex 5600+ TripleTOF (QTOF) high-resolution mass spectrometer. MS and MS/MS analyses elucidated the structures of the most abundant metabolites. Twelve metabolites were identified in total. N-Dealkylation and monohydroxylation of the piperidine ring were the dominant metabolic pathways. Two N-oxide metabolites and one glucuronide metabolite were observed. Surprisingly, ester hydrolysis was not a major metabolic pathway for carfentanil. While the human liver microsomal system demonstrated rapid clearance by CYP enzymes, the hepatocyte incubations showed much slower clearance, possibly providing some insight into the long duration of carfentanil’s effects.
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