Abnormal Cannabidiol

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Abnormal cannabidiol is a synthetic cannabidiol that acts as an agonist at the GPR55 cannabinoid (CB) receptor and is highly selective for GPR55 over CB1 and CB2 receptors (EC50s = 2.5, >30, and >30 µM, respectively).1 It is also a full agonist at GPR18, with an EC50 value of 0.835 µM for inducing p44/42 MAPK phosphorylation in HEK293 cells stably transfected with GPR18.2 Abnormal cannabidiol regulates the migratory activity of murine BV-2 microglial cells, with an EC50 value of 0.6 µM.3 It induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1) in retinal arterioles, an effect that can be blocked by apamin (Item No. 17082), a calcium-sensitive potassium channel blocker.4,5 It also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 µg/g or when administered directly into the rostral ventrolateral medulla.

Catalogue number: A108910
Chemical name: Abnormal Cannabidiol
Synonyms: 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; CAY10429; trans-(-)-4-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; trans-(-)-4-[3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Impurity:
CAS Number: 22972-55-0
Alternate CAS #: NA
Molecular form.: C₂₁H₃₀O₂
Appearance: Clear Colorless to Pale Yellow Oil
Melting Point: No data available
Mol. Weight: 314.46
Storage: -20°C Freezer, Under inert atmosphere
Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: Abnormal Cannabidiol is a potent and selective GPR55 agonist.
Dangerous Goods Info: NA
References:
Quantity

10mg, 50 mg, 100mg

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