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6-APB Powder Chemical is a substituted phenethylamine which has a similar chemical structure to MDMA – like the most phenethylamines it is a
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global research community.
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What is 6-APB?
Buy 6-APB Powder online (2-Aminopropyl)benzofuran or 6-APB is an entactogen and a strong stimulant belonging to phenethylamine and benzofuran class. 6-APB powder is white and crystalline.
Like other compounds containing benzofuran, it consists of phenylethylamine core that is bonded with an amino group (NH2) through an ethyl chain, and with an additional methyl placement at R?. The methyl substitution at RN position as seen with MDA is not present in 6-APB. The oxygen of 6-APB is substituted at benzofuran ring, which in turn is fused at phenyl ring (R3 & R4).
6-APB is analogous to narcotic substance MDMA, which is the basic chemical for the manufacture of Ecstasy tablets. The chemical was studied and synthesized in 1993 by a medicinal chemist David E. Nichols, where he first utilizes it for psychotherapy. It is available online as research chemical from online vendors, but is not sold for human consumption.
There is insufficient data available on the pharmacological properties, metabolism and toxicity of 6-APB. As it?s a new chemical, therefore its history in human usage is also short. It has a potent entactogenic and stimulant effect and can elicit wide range of side effects, so it is advisable to take precautions and observe necessary harm reduction practices, as it is likely to produce addiction and dependence if used improperly. In cases where the addiction builds up, discontinuation must be done step-wise, as worse withdrawal effects may occur if they are discontinued abruptly.
Bioactivity of 6-APB
6-APB pharmacologically can be described as a serotonin-norepinephrine-dopamine re-uptake inhibitor (SNDRI) possessing strong Ki values for the norepinephrine transporter (NAT), dopamine transporter (DAT) and serotonin transporter (SERT).
6-APB is also a potent agonist of three main serotonin receptors (5-HTP2A/B/C), though it elicit higher affinity and selectivity for the serotonin receptor 5-HT2B only. It is involved in the release of these monoamine neurotransmitters. As these neurotransmitters has been linked to the modulation of brain?s capability to judge joy, pleasure, motivation, reward etc, so when their re-uptake is either inhibited or the release is enhanced, the neurotransmitter are accumulated within the synaptic cleft to exceptionally in greater quantity, in order to be available to be used again. As this kind of neuronal activation is seen at different regions of brain, this consequently produces euphoria, physical stimulation, relaxation, and disinhibition. On long-term use, it is likely to produce cardiotoxic effects due to the strong agonistic effect for 5-HT2B receptor.
It has a strong and produces long-lived array of enactogenic effect, and psychedelic effects of mild intensity, that can be numerated as suppression of anxiety, disinhibition, strong feeling of empathy, sociability and affection, muscle relaxation, altered perception and euphoria.
Expected Physical effects of 6-APB
The expected physical effect of 6-APB according to subjective effects index and personal experiences includes various physical, cognitive, paradoxical effect and after effects. There adverse effects can also cause significant injury or death.
6-APB produces significant stimulation as well as sedation, so when this drug is taken, people generally feel a mixed perception of body heaviness and lightness. It can lead to loss of body fluid and produces spontaneous physical sensations, euphoria, enhanced tactile sensations, increased stamina and body control, loss of temperature regulation, due to which body temperature can fluctuate. It can also produce nystagmus, abnormal heartbeat, increase in heart rate and blood pressure, higher perspiration, dry mouth, difficulty in urination, appetite suppression, pupil dilation, temporary erectile dysfunction, teeth grinding or seizure.
It produces cognitive effects such as suppression of anxiety, disinhibition, cognitive euphoria, increase in empathetic and sociability behavior. Some may experience increased novelty, focus or creativity, immersion, self-motivation and emotionality, personal meaning and increase sense of humor. Also, appreciation for music, mindfulness, increased libido, thought deceleration, wakefulness, time distortion may likely to occur. People may experience existential self-realization, unity and interconnectedness.
Some visual effects have been reported that includes color enhancement, pattern recognition enhancement, distortion of tracers and symmetrical texture repetition, geometry, or experiencing hallucinatory state. Some auditory effects may also occur.
The after affects may present with anxiety, irritability, de-realization, appetite loss, brain zaps, cognitive fatigue, depression, sleep paralysis, decreased motivation, thought deceleration and disorganization, unusual suicidal thoughts and wakefulness.
Dosage Information for 6-APB
The dose required to produce stimulant effect is 15 ? 30 mg, whereas milder effects may elicit at a dosage of 30 ? 60 mg, however 60 ? 90 mg is commonly given dose. Stronger effects are obtained in a dosage of 90 ? 120 mg and dose exceeding 120 mg is considered much heavy dose.
The total duration of action lasts for 7 ? 10 hours, wherein the onset is within 45 ? 75 minutes, coming up is seen at 60 ? 120 minutes and peak effects showing after 3 ? 5 hours, while offsets occurs at around 2 ? 3 hours.
The after-effects of this drug last for 6 ? 48 hours, after the last dose taken.
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